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Novel roles for protein disulphide isomerase in disease states: A double edged sword

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In particular, MPTP intoxication typically downregulates key autophagy regulators (LC3-II, beclin-1, parkin, PINK1), but schisandrin A treatment partially preserved the levels of these proteins, implying that it enhances autophagic clearance of toxic aggregates (59, 60)

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found that significant enrichment of Th2 and Th17 lymphocyte subsets identified within bronchoalveolar lavage samples obtained from individuals diagnosed with asthma could trigger IL-4 overproduction and subsequently augment the capability of inducing glucocorticoid resistance in vitro [131]